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重组人 IFN gamma 蛋白 (his-tag)

产品编号：XC989997-500µg 英文名称：Recombinant Human IFN gamma Protein 中文名称：重组人 IFN gamma 蛋白

商品名称：重组人 IFN gamma 蛋白 (his-tag)

所属分类：

重组蛋白

电子邮箱：

taoweihong@constreambio.com

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产品参数

产品编号	XC989997-500µg
英文名称	Recombinant Human IFN gamma Protein
中文名称	重组人 IFN gamma 蛋白
别名	IFG,IFI,IFNG，IFN gamma,Interferon Gamma
Gene ID	3458
研究领域	Neuroinflammation
蛋白来源	Human
表达宿主	E. coli
蛋白标签	N-terminal 6xHis-tag
内毒素	<1 EU/mg as determined by TAL test
蛋白纯度	>95% purity by SDS-PAGE under reduced conditions.
表达区域	Human IFN-gamma Protein is expressed from E. coli cells. It contains AA （Gln 24 - Gln 166） (Accession # P01579), This protein was fused with the His tag at the N-terminus.
预测分子量	The protein has a calculated MW of 18 kDa
性状	Liquid
缓冲液	0.2 μm filtered in PBS, pH 7.4, 50% glycerol

保存条件

Aliquot and store at -20°C to -80°C,Avoid repeat freeze-thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍

IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN gamma has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activator of macrophages and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. The IFNG monomer consists of a core of six α-helices and an extended unfolded sequence in the C-terminal region. IFN gamma is critical for innate and adaptive immunity against viral and intracellular bacterial infections and tumor control. Aberrant IFN gamma expression is associated with some autoinflammatory and autoimmune diseases. The importance of IFN gamma in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFNG also promotes NK cell activity.