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重组人 IL-10 蛋白 (his-tag)

产品编号：XC986997-500μg 英文名称：Recombinant Human IL-10 Protein 中文名称：重组人IL-10 蛋白

商品名称：重组人 IL-10 蛋白 (his-tag)

所属分类：

重组蛋白

电子邮箱：

taoweihong@constreambio.com

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产品参数

产品编号	XC986997-500μg
英文名称	Recombinant Human IL-10 Protein
中文名称	重组人IL-10 蛋白
别名	CSIF; IL10; IL10A; Interleukin-10; TGIF
Gene ID	3586
研究领域	Neuroinflammation
蛋白来源	Human
表达宿主	E. coli
蛋白标签	N-terminal 6xHis-tag
蛋白纯度	>95% purity by SDS-PAGE under reduced conditions.
表达区域	Human IL-10 Protein is expressed from E. coli cells. It contains AA （Ser 19 - Asn 178） (Accession # P22301), This protein was fused with the His tag at the N-terminus
预测分子量	The protein has a calculated MW of 18.5 kDa
性状	Liquid
缓冲液	0.2 μm filtered in PBS, pH 7.4, 50% glycerol

保存条件

Aliquot and store at -20°C to -80°C,Avoid repeat freeze-thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍

IL-10 is an anti-inflammatory cytokine that belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells, and other cell types, while it is produced primarily by monocytes and to a lesser extent by lymphocytes. IL-10 is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and also in a certain subset of activated T cells and B cells. IL-10 has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. The importance of interleukin 10 for counteracting excessive immunity in the human body is revealed by the fact that patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant IL-10. IL-10 inhibits the synthesis of some cytokines, including IFN-gamma, IL-2, IL-3, TNF, and GM-CSF produced by activated macrophages and by helper T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen-presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production.