重组人 IL-18蛋白 (no tag)
- 商品名称： 重组人 IL-18蛋白 (no tag)
详情描述
- 产品描述
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产品参数
产品编号 XC987996-500μg 英文名称 Recombinant Human IL-18 Protein 中文名称 重组人IL-18 蛋白 别 名 IGIF; IL-18; IL-1g; IL1F4; Interleukin 18 Gene ID 3606 研究领域 Neuroinflammation 蛋白来源 Human 表达宿主 E. coli 蛋白标签 no tag 内毒素 <1 EU/mg as determined by TAL test 蛋白纯度 >95% purity by SDS-PAGE under reduced conditions 表达区域 Human IL-18 Protein is expressed from E. coli cells. It contains AA( Tyr 37 - Asp 193 )(Accession # Q14116) 预测分子量 The protein has a calculated MW of 17 kDa 性 状 Liquid 缓冲液 0.2 μm filtered in PBS, pH 7.4, 50% glycerol. 保存条件
Aliquot and store at -20°C to -80°C,Avoid repeat freeze-thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is aproinflammatory cytokine that belongs to the IL-1 superfamily and isproduced by macrophages and other cells. This cytokine can induce theIFN-gamma production of T cells. The combination of IL-18 and IL12 hasbeen shown to inhibit IL4 dependent IgE and IgG1 production, andenhance IgG2a production of B cells. IL-18 binding protein (IL18BP) canspecifically interact with this cytokine, and thus negatively regulate itsbiological activity. IL-18 is an IL-1−like cytokine that requires cleavage withcaspase-1 to become active, was found to increase IgE production in aCD4+ T cells-, IL-4− and STAT6−dependent fashion. IL-18 and T cellreceptor−mediated stimulation could induce naïve CD4+ T cells to developinto IL-4−producing cells in vitro. Thus, caspase-1 and IL-18 may be criticalin regulation of IgE production in vivo, providing a potential therapeutictarget for allergic disorders. IL-18 production in primary synovial culturesand purified synovial fibroblasts was, in turn, upregulated by TNF-α and IL1β, suggesting that monokine expression can feed back to promote Th1cell development in synovial membrane. Besides, synergistic combinationsof IL-18, IL-12, and IL-15 may be of importance in sustaining both Th1responses and monokine production in RA
图片数据
SDS-PAGE 电泳
Lane M: Protein marker Lane 1: Reduced sample
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